2013-03-02, 17:00 | Link #1721 | |
NYAAAAHAAANNNNN~
Join Date: Nov 2007
Age: 35
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I remember reading somewhere that telomere do extend themselves naturally by combining with another gene sequence, but sometimes it results in the creation of rare cells which are the cause of cancer.
Did I get it right? Or can you explain how long telomeres may cause cancer? Quote:
Also, it would be one hell of a cleanup if the cell replication becomes a biomass - cells are known to be adaptive in environments and it would take more than a flamethrower to clean it up.
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2013-03-02, 17:42 | Link #1723 | ||
Love Yourself
Join Date: Mar 2003
Location: Northeast USA
Age: 38
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There is a protein that can elongate telomeres known as telomerase. Telomerase is tightly regulated under normal conditions. Stem cells express it, some of the rapidly dividing cells that I mentioned earlier express it, but most other cells either don't express it or only express it in small amounts. Cancer cells and immortalized cell culture lines that we use in research readily express telomerase, allowing them to divide indefinitely and bypass the Hayflick limit. At this point you may be questioning what it is about telomerase that makes cells go bad. Immortalized cancer cells express telomerase, but so do our stem cells: what's the problem? Telomerase itself isn't the problem, but it's an enabler. As I mentioned before, cellular replication is under tight control, and in order for a cell to become cancerous a few mutations needs to occur. Genes encoding proteins that guard against DNA damage and further mutations and that restrict cellular replication need to be knocked out, and genes encoding proteins that instigate cellular division need to be constitutively active. Even if all of those things happen, the Hayflick limit can put an end to many cancers. The point is that mutations aren't uncommon, and the formation of potential cancers in your body isn't uncommon, either. How many potential cancers are stopped prematurely because of the Hayflick limit? Since we don't have any animal model where telomerase is expressed freely it's impossible to say at this point in time, but it seems that many cancers are bypassing the natural replication limitations through telomerase. We already know that people with a heterozygous mutation (knockout of one of two copies of a gene) that disables a gene protective against cancer have a much higher likelihood of developing certain types of cancer (with the specific type depending on which protein was knocked out); knocking out the protective mechanism provided by telomeres would no doubt have a similar effect. Quote:
I wish they were that durable! It would have made my work a lot easier.
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2013-03-02, 18:39 | Link #1726 | |
Senior Member
Join Date: Dec 2010
Location: Gensokyo
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Most research now go on creating artificial life, with things like Foldamere. At least for our dear pharmatical society. |
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2013-03-03, 13:37 | Link #1728 | ||
今宵の虎徹は血に飢えている
Join Date: Jan 2009
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Quote:
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2013-03-04, 05:29 | Link #1729 | |
NYAAAAHAAANNNNN~
Join Date: Nov 2007
Age: 35
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U.S. baby's HIV infection cured through very early treatment
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2013-03-04, 08:10 | Link #1730 | |
Love Yourself
Join Date: Mar 2003
Location: Northeast USA
Age: 38
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Quote:
While this article inspires thoughts of new drugs or techniques, the only difference with this infant was the course of therapy. It was given more aggressively at an earlier stage than normal. While that may cause a revision in current treatment protocols for HIV-infected infants, remember that we're dealing with a sample size of one. Repeat these results with a few hundred (and don't kill anyone in the process), and then we'll have something to get some excitement over.
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2013-03-04, 10:22 | Link #1732 | |
NYAAAAHAAANNNNN~
Join Date: Nov 2007
Age: 35
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2013-03-04, 15:48 | Link #1735 |
Senior Member
Join Date: Jan 2008
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Space race under way to create quantum satellite:
"In this month’s special edition of Physics World, focusing on quantum physics, Thomas Jennewein and Brendon Higgins from the Institute for Quantum Computing at the University of Waterloo, Canada, describe how a quantum space race is under way to create the world’s first global quantum-communication network." See: http://www.defencetalk.com/space-rac...tellite-47020/ |
2013-03-06, 05:16 | Link #1736 | ||
NYAAAAHAAANNNNN~
Join Date: Nov 2007
Age: 35
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Korean operators warn Europe of "curse" of 4G networks Quote:
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2013-03-06, 14:34 | Link #1737 | |
He Without a Title
Join Date: Feb 2008
Location: The land of tempura
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Clearly we just aren't data hungry /end rand PS: these are Portuguese prices, I'm sure (or at least hope) other European countries aren't as rapped as we are.
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2013-03-06, 14:54 | Link #1738 |
temporary safeguard
Join Date: May 2004
Location: Germany
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Sounds about right.
I'm paying 30€ for 10GB, but that's only UMTS. On the other hand this service is so congested that I'm getting about 100kbit/s max from it most of the time... except for late @ night / early morning when it's suddenly back to mb/s. So I won't be hitting the volume limit. Clearly because I'm not data hungry enough. |
2013-03-07, 11:16 | Link #1740 |
Takao Tsundere Cruiser
Join Date: Oct 2008
Location: Classified
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Processed meat 'early death' link
I'm still gonna eat meat but not that much. Frozen Android phones give up data secrets Salt linked to immune rebellion in study
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